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777 coins has some unique in-house software on their games. Their blackjack has minimal animations but offers a strategy table and an "genius" option which tells you the most optimal moves to make. They have games such as plinko and slots as well but I generally do not play those. Their cashier seem to work fine with deposits requiring one deposit and withdraws instant, I did have a few spotty issues on withdraws with them not being instant instead taking 10-20 hrs to process and these were pretty small withdraws but it seems to be isolated cases and overall it works smooth.
Coinroyale focuses on those that like to play table games. They are one of the few that offer multi-hand blackjack and the blackjack has decent rules on it. They also have a first deposit bonus which is allowed to clear the wagering on blackjack. They have roulette,baccarat, a simple slot and a dice site. I wouldn't deposit here just to play the slot or dice site since many sites offer more complex and finished offerings though. I did have an issue with a deposit not crediting once and it took 20+ hrs for them to email me back to resolve the issue but it was a one time thing, I would trust this site overall. Deposits take 1 conf and withdraws a decent.
Directbet is a favorite of mine, there is no need for an account, you simply make a wager on their site and send coins to an address, if you win the bet resolves and you are instantly paid out. The odds on their site are not that great unfortunately when you compare them to sites such as cloudbet and nitrogen. They also offer on chain dice gambling which is rare nowadays as well as their own "in house" game of all in poker flips where you can determine your starting hand and your opponents starting hand and play out a poker game which instantly pays out if you win, it carries about a 2% house edge if I remember correctly. If you can stomach a bit lesser odds in favor of not having to have an account then Directbet is a great place to play.
CloudBet has been around forever and has a reputation for being a safe spot to play. There has been reports on some forum that they will limit you on their sportsbook if you win to much but it has not happened to me personally and I have won 1BTC+ on their games. Their slots have a few different providers available to US citizens that you don't see elsewhere namely PlayandGo software which is a huge plus. Their live casino is fun with min bets at 1MBC on games such as roulette and baccarat and 10MBC at blackjack. Deposits are nearly instant and withdraws are instant in most cases, they do offer some bonuses but nothing huge or notable.
I've been a member of Betonline for some time and they are an interesting site to play on, one of the major negatives for bitcoin depositors is that Betonline will charge you high fees on both deposits and withdraws through bitcoin, while you normally are used to 100 bit withdraw fees Betonline takes much much more, be sure to inquire with their live support to see if you can get withdraws fees waived somehow. Beyond that they have a good sportsbook with on par odds with the industry in general, they offer access to live casino games as well as a virtual casino. They offer poker with lots of traffic, this is the play you want to be if you are in the United States and want a populated poker room. Good site but be careful of the fees.
Nitrogen sports has been around for a long time in the bitcoin gambling world and is trusted name. Their sportsbook often has better odds then the competitors and their interface by far is the best in the field. They often have good live game availability as well as high limits in general. They carry both Blackjack and Dice(with a jackpot) if you want to try, I generally steer clear of those though. You can also play in their own "in house" poker room that runs on pretty solid software, traffic is a bit light though. Overall the best in the field hands down for sports betting, deposits are quick and withdraws are instant.
Fortune-Jack has a wide selection of games and they are always adding more. If you are on a low bankroll I would avoid their slots since they have very high min bet requirements. Their dice side has a faucet as well as a Jackpot you can try to win. Their live games are fun but once again have very high min bet requirements. The binary trader side is minimalist in options but you can win off of it, I wouldn't deposit here just to play that though. The poker is pretty new on this site but it looks like it has decent traffic and a selection of free-rolls you can try to win at. Deposits are fast and withdraws just take a few minutes a good site to play on.
Crypto-Games is a good site to play on, if you don't have any coins you can use their faucet once every 3 minutes and the faucet is one of the higher amounts offered around. Their dice game rolls fast both on manual and auto and has the availability to hook up a 3rd party dice bot through their API. I don't often play their blackjack,slots or lotto but the times I have they all seem to run with no issues. Deposits are quick and withdraws are instant. No issues with playing here.
Good site to use, it has poker and slots. The slots have several different providers available to people in the United States instead of the usual Betsoft slots you normally see. The slots have low min bets so you can play on a small bankroll for a long time, they also have a selection of virtual table games but the live games are blocked for US citizens. The poker room has decent traffic with small stake cash games going all the time and a variety of tournaments with low-mid size buyins. The only downside I get from this site is that it frequently has downtime and that withdraws are manual instead of instant, withdraws normally take <10 hrs to process though so its not a huge deal.